Ethambutol

SKU: orb1908979

Description

Ethambutol is an antibacterial agent that inhibits arabinosyl transferase, disrupting mycobacterial cell wall biosynthesis. It is widely used in tuberculosis research and serves as a tool compound in animal models for studying hyperuricemia and optic neuropathy mechanisms.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	74-55-5
MW	204.31
Purity	99.92%
Formula	C₁₀H₂₄N₂O₂
SMILES	[C@H](NCCN[C@@H](CC)CO)(CC)CO
Target	Antibiotic
Solubility	H2O:180 mg/mL (881.01 mM);DMSO:80 mg/mL (391.56 mM)

Bioactivity

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Target IC50	HT29 cells:25.5±4.7 µg/mL\|SW620 cells:5.5±2.1 µg/mL\|HCT116 cells:5.5±1.0 µg/mL\|MCF-7 cells:11.1±1.1 µg/mL\|DLD1 cells:7.8±2.2 µg/mL\|SW480 cells:5.8±1.3 µg/mL Read more...
In Vivo	Ethambutol (250 mg/kg, administered by gavage once daily for 23 days) can induce hyperuricemia and cause pathological damage and inflammatory reactions in the thymus and spleen, manifested by thymic atrophy, fusion of the cortex and medulla, congestion of the splenic sinuses, and hemosiderin deposition [4,5]. In addition, Ethambutol (35 mg/kg/day, orally for 30 days) can induce optic neuropathy, leading to ganglion cell damage, increased retinal ganglion cell (RGC) density, and thickening of the RGC layer . Read more...
In Vitro	The MTT or CCK-8 assays showed that Ethambutol (0-50µg/mL) exerted a time-dependent inhibitory effect on cell proliferation in six cell lines, including SW480 and SW620. The IC50 values for different cell lines ranged from 5.37 to 31.54µg/mL over 24-72 hours. In the RGC-5 retinal ganglion cell experiment, after treating the cells with 4mM Ethambutol for 8 hours, flow cytometry and Western blot analysis confirmed a significant increase in cell apoptosis, as well as upregulation of autophagy markers such as PI3C3 and Beclin-1. Additionally, treatment of Mycobacterium smegmatis with 10µg/mL Ethambutol followed by acid hydrolysis combined with HPLC and enzyme activity analysis showed changes in arabinogalactanase activity. Read more...

Storage & Handling

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Storage	keep away from moisture,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Myambutol, Ethambutol, EMB

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Compound Identifiers

PubChem CID

14052 ↗

Key Properties

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No computed properties available.

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Ethambutol (orb1908979)

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CAS Number:	1129526-23-3
MW:	212.36
Formula:	C₁₀H₁₆D₈N₂O₂

MW:	208.33
Formula:	C₁₀H₂₀D₄N₂O₂

CAS Number:	10054-05-4
MW:	204.31
Formula:	C₁₀H₂₄N₂O₂

Ethambutol

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Ethambutol (orb1908979)

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