Ethylhydrocupreine hydrochloride

SKU: orb1303259

Description

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	3413-58-9
MW	376.92
Purity	98.13%
Formula	C₂₁H₂₉ClN₂O₂
SMILES	Cl.[H][C@]1(C[C@@H]2CCN1C[C@@H]2CC)[C@H](O)c1ccnc2ccc(OCC)cc12
Target	Antibacterial,Parasite
Solubility	H2O:50 mg/mL (132.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.61 mM);DMSO:125 mg/mL (331.64 mM)

Bioactivity

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Target IC50	P. falciparum:25.75 nM (IC50)
In Vivo	The highest tolerated dose of ethylhydrocupreine hydrochloride for guinea pigs by intrapleural injection is about 0.2 to 0.3 cc. of a 1:100 solution per 100 gm. of weight, corresponding to 2 to 3 cc. of solution or 0.02 to 0.03 gm. of the drug per kilo of weight. The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs . Read more...
In Vitro	The mutation rate towards Ethylhydrocupreine (Optochin) resistance in three capsulated S. pneumoniae strains (S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255, and S. pneumoniae ATCC 49619) was determined through fluctuation analysis. It was found that for these strains, subinhibitory concentrations of penicillin noticeably increased the mutation rate (measured as mutations per cell division) to Ethylhydrocupreine (Optochin) resistance, with an enhancement ranging from 2.1- to 3.1-fold . Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Ethylhydrocupreine, Ethylhydrocupreine hydrochloride, Ethylhydrocupreine Hydrochloride, ggTas2r1, ggTas2r2, ggTas2r7, Inhibitor, inhibit, Optochin, Optochin Hydrochloride, Optochin hydrochloride, Parasite, bitter, antimalarial, Antimicrobial, Bacterial, bactericidal, S. pneumoniae, taste

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Compound Identifiers

PubChem CID

16219340 ↗

Key Properties

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No computed properties available.

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