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Etomoxir

SKU: orb1689975

Description

Etomoxir is a potent and irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT1A), effectively blocking fatty acid oxidation. This small molecule is widely used in metabolic research, including studies on macrophage polarization, cardiac energetics, and cancer cell metabolism in both in vitro and in vivo models.

Research Area

Cell Biology, Metabolism Research

Images & Validation

Key Properties

CAS Number124083-20-1
MW326.82
Purity99.39% (May vary between batches)
FormulaC17H23ClO4
SMILESC(OCC)(=O)[C@@]1(CCCCCCOC2=CC=C(Cl)C=C2)CO1
TargetCPT,Antioxidant,Apoptosis
SolubilityDMSO:250 mg/mL (764.95 mM);0.5% CMC-Na:12.5 mg/mL (38.25 mM)

Bioactivity

Target IC50
KB cells (human):2.76 μM|faTT cellsy acid (Hepatocyte cells,rat):10 μM|faTT cellsy acid (Hepatocyte cells,guinea pig):1 μM|faTT cellsy acid (Hepatocyte cells,human):0.1 μM
In Vivo
METHODS: To study the inhibition of cardiac CPT-I activity by Etomoxir, rats were injected with Etomoxir daily for 8 consecutive days at a dose of 20 mg/kg. RESULTS: Rats treated with Etomoxir showed a 44% reduction in cardiac CPT-I activity. METHODS: To study the effects of Etomoxir on blood glucose levels, weight gain, hind limb muscle mass, heart mass and liver mass, Lewis rats were treated with 20 mg/kgEtomoxir for 8 days. RESULTS: Treating Lewis rats with Etomoxir for 8 days did not change the blood glucose level, did not affect general growth characteristics such as weight gain, nor did it affect the muscle mass of the hind limbs. However, both the heart mass and liver mass increased significantly by 11%.
In Vitro
METHODS: A2780/PTX cells were treated with Etomoxir (1, 10, 100, 1000, 10000, 100000 nM) and paclitaxel (1, 10, 100, 1000, 10000, 100000 nM) for 48 hours, and the growth inhibition of the cells was detected by the CCK-8 method. RESULTS: The IC50 value of Etomoxir decreased from 1589.5 ± 62.5 nM to 817.4 ± 79.7 nM.

Storage & Handling

Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Antioxidant, (R)-(+)-Etomoxir, CPT1, Etomoxir

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Key Properties

No computed properties available.

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Etomoxir (orb1689975)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 910.00
5 mg
¥ 1,430.00
1 ml x 10 mM (in DMSO)
¥ 1,560.00
10 mg
¥ 2,080.00
25 mg
¥ 3,120.00
50 mg
¥ 4,940.00
100 mg
¥ 7,670.00
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