Etretinate

SKU: orb1300426

Description

Etretinate is an oral aromatic retinoid effective in treating psoriasis and various dermatoses. It functions by activating retinoid receptors to promote cell differentiation, suppress proliferation, and reduce inflammatory cell infiltration. This mechanism has been validated in both in vitro cellular assays and in vivo animal models of hyperproliferative skin disorders.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	54350-48-0
MW	354.48
Purity	99.48% (May vary between batches)
Formula	C₂₃H₃₀O₃
SMILES	CCOC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\c1c(C)cc(OC)c(C)c1C
Target	Apoptosis
Solubility	10% DMSO+90% Corn Oil:2.5 mg/mL (7.05 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:65 mg/mL (183.37 mM);DMSO:65 mg/mL (183.37 mM)

Bioactivity

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In Vivo	There is a significant decrease in mean dermal thickness (P < 0.05) and changes in collagen bundles in the etretinate-treated mice group for a 28-day period compared to control groups. TUNEL assay shows that the density of TUNEL-positive cells in the dermis of etretinate-treated mice for a 14-day period is significantly increased (P < 0.05). The ratio of procollagen α 1 (I) chain to β actin mRNA from etretinate-treated mice for a 1-day period decreased significantly compared to that of the control mice, but the ratio from etretinatetreated mice for a 14-day period increased significantly (P < 0.05). Etretinate reduces dermal thickness, and suppresses the appearance of skin lesions by inducting apoptosis and perhaps regulation of cytokine expression in MRL/lpr mice.
In Vitro	K03861 inhibits CDK2 activity by competing with binding of activating cyclins.
Cell Research	The HSC-5 cells are plated in 96-well plates at a density of 1.5×103 per 100 μL and used for experiments. Preliminary experiments are performed to determine the effective dose and cytotoxicity of etretinate. The cells are incubated for 72 h with etretinate at concentrations of 5, 10, 25 and 50 nmol⁄L [dissolved in saline containing 0.0001% dimethyl sulfoxide (DMSO)]. The cells are then incubated for a further 2 h with or without 200 μmol⁄L ALA (Sigma). Each plate is then irradiated using a metal halide lamp at doses of 10, 20, 40 and 80 J⁄cm2 (Only for Reference)

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Apoptosis, inhibit, Ethyl etrinoate, Etretinate, Etretinato, Inhibitor, Retinoid, Ro 10-9359, Tegison

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Compound Identifiers

PubChem CID

5282375 ↗

Key Properties

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No computed properties available.

Protocol Information

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Purity:	>98% (HPLC)
CAS Number:	54350-48-0
MW:	354.48
Formula:	C₂₃H₃₀O₃

Etretinate

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Etretinate [orb1222077]

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