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Evocalcet

SKU: orb1219698

Description

Evocalcet has an activating effect on the calcium-sensing receptor (CaSR).

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number870964-67-3
MW374.48
Purity>98% (HPLC)
FormulaC24H26N2O2
SMILESC[C@@H](N[C@H]1CCN(C1)c1ccc(CC(O)=O)cc1)c1cccc2ccccc12
TargetCaSR
SolubilityDMSO:30 mg/mL (80.11 mM; Need ultrasonic and warming)

Bioactivity

In Vivo
Animal model: Male Sprague Dawley chronic kidney disease (CKD) rats with adenine induced secondary hyperparathyroidism (SHPT). Dosage: 0.03 and 0.3 mg/kg. Administration: Oral Administration; 0.03 and 0.3 mg/kg, once. Result: Decreased the serum PTH and Ca levels at a dose of 0.3 mg/kg.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

KHK7580

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  • Evocalcet [orb1308317]

    98.41% (May vary between batches)

    870964-67-3

    374.48

    C24H26N2O2

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 200 mg
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Protocol Information

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5 mg
$ 130.00
10 mg
$ 180.00
25 mg
$ 350.00
50 mg
$ 540.00
100 mg
$ 780.00
500 mg
$ 1,670.00