Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Page Not Found
Cart summary

You have no items in your shopping cart.

Evodenoson

SKU: orb1697251

Description

Evodenoson (ATL313) is a selective adenosine A2a receptor agonist used in research for ocular diseases, oncology, and immunology. Its applications include studies in models of glaucoma and hematologic tumors, supported by both in vitro and in vivo experimental data.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

−
Evodenoson

Key Properties

−
CAS Number844873-47-8
MW499.52
Purity99.74% (May vary between batches)
FormulaC23H29N7O6
SMILESO[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=C(C#CCC4CCN(C(OC)=O)CC4)N3)O[C@H](C(NC5CC5)=O)[C@H]1O
TargetAdenosine Receptor
SolubilityDMSO:50 mg/mL (100.1 mM)

Bioactivity

−
In Vivo
The rats were divided into 3 groups: Group 1 received a continuous intravenous infusion of saline given 10 min prior to ischemia and throughout reperfusion (n=8); Group 2 received a continuous intravenous infusion of 10 ng/kg/min of ATL 313 given 10 min prior to ischemia and throughout reperfusion (n=8); and group 3 received an intravenous bolus of ATL 313 (900 ng/Kg body weight) given 10 min prior to ischemia, and continuous intravenous infusion of 10 ng/kg/min of ATL 313 started at 20 min after ischemia and throughout reperfusion (n=8). After the euthanasia of the rats, the hearts were harvested for the assessment of the risk zone and zone of necrosis of the left ventricle. Conclusion: A(2A)AR agonist ATL 313 significantly reduced infarct size and improved LV contractility at the end of reperfusion assessed by LV dp/dt at a dose of 900 ng/Kg. The mechanisms for the observed cardioprotection effect of ATL 313 remain to be determined.

Storage & Handling

−
Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

−
AdenosineReceptor, Adenosine Receptor, A2A, ATL 313, ATL313, ATL-313, Evodenoson, DE 112, DE112, DE-112
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
11627443 ↗

Key Properties

−
No computed properties available.

Protocol Information

Find More Protocols

Available Sizes

Select a size below

1 mg
$ 290.00
5 mg
$ 670.00
10 mg
$ 990.00
25 mg
$ 1,870.00
50 mg
$ 2,500.00
100 mg
$ 3,760.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry
Need technical support? Find your Distributor Return and Tax Policy

Email

[email protected]

UK Office

+44 (0)1223 859353

US Office

+1 (415) 906-5211

CN Office

+86 (27)-87663101

Distributors

biorbyt.com/distributor