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(E),(Z)-RNF5 agonist 1

SKU: orb3174992

Description

(E),(Z)-RNF5 agonist 1 (Compound Analog-1) is an RNF5 agonist that enhances the ubiquitin-mediated degradation of the SARS-CoV-2 E protein. It effectively inhibits SARS-CoV-2 replication and significantly reduces lung pathology and systemic inflammation in mouse infection models. Additionally, (E),(Z)-RNF5 agonist 1 exhibits potent cytotoxicity against neuroblastoma and melanoma cells. This compound is relevant for cancer and antiviral research.

Images & Validation

Key Properties

CAS Number2231731-82-9
MW370.47
FormulaC22H18N4S
SMILESN(\C(=N\C1=CC=CC=C1)\C2=CC=CC=C2)=C\3/N(C(C)=NS3)C4=CC=CC=C4
TargetE1/E2/E3 Enzyme,SARS-CoV

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information