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Falcarindiol

SKU: orb1744539

Description

Falcarindiol is an orally bioavailable polyacetylene that suppresses inflammation and cell proliferation. It inhibits LPS-induced NO production in macrophages by targeting the JAK/STAT pathway, reducing JAK1/JAK2 phosphorylation and STAT1 nuclear translocation to downregulate iNOS expression. This mechanism supports its research in inflammatory and cancer studies using both in vitro and in vivo models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number55297-87-5
MW260.37
Purity99.38%
FormulaC17H24O2
SMILESC([C@H](/C=C\CCCCCCC)O)#CC#C[C@H](C=C)O
TargetNOD,JAK,NOS,STAT
SolubilityDMSO:≥ 25 mg/mL

Bioactivity

In Vivo
Falcarindiol (7 μg/g, diet) significantly upregulates the gene expression of cholesterol transporter (ABCA1) in colorectal tumor tissues of 5-week-old male F344 strain rats .
In Vitro
Falcarindiol (1-20 μM) exhibited low toxicity towards hMSCs and HT-29 cells, while demonstrating cytotoxicity at concentrations above 50 μM . After 24 hours of treatment with Falcarindiol (5 μM), the expression of the PPARγ2 gene in HT-29 cells was significantly upregulated .

Storage & Handling

Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Falcarindiol

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Key Properties

No computed properties available.

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Falcarindiol (orb1744539)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
¥ 1,560.00
5 mg
¥ 2,990.00
10 mg
¥ 4,420.00
25 mg
¥ 7,020.00
50 mg
¥ 9,880.00
100 mg
¥ 13,390.00
DispatchUsually dispatched within 8-10 weeks
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