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FAP-PI3KI1

SKU: orb1982974

Description

FAP-PI3KI1 is a fibroblast-activated protein (FAP)-directed small molecule that selectively inhibits PI3K in FAP-expressing cells, such as those in idiopathic pulmonary fibrosis (IPF). It demonstrates efficacy in reducing collagen production and deposition in relevant in vitro and in vivo fibrotic disease models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number2415941-98-7
MW1177.19
FormulaC52H48F4N10O12S3
SMILESCOc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2nccc(-c3ccc(COC(=O)OCCSSC[C@H](NC(=O)CCC(=O)NCc4cc(ccn4)C(=O)N[C@@H](C)C(=O)N4CC(F)(F)C[C@H]4C#N)C(O)=O)nc3)c2c1
TargetPI3K,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

Protocol Information