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FCPR03

SKU: orb1303542

Description

FCPR03

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1917347-65-9
MW299.31
Purity99.94%
FormulaC15H19F2NO3
SMILESCC(C)NC(=O)c1ccc(OC(F)F)c(OCC2CC2)c1
TargetPDE
SolubilityDMSO:95 mg/mL (317.4 mM)

Bioactivity

Target IC50
PDE4 catalytic domain:60 nM (IC50)|PDE4D7:47 nM (IC50)|PDE4B1:31 nM (IC50)
In Vivo
In adult male Sprague-Dawley rats following cerebral ischemia-reperfusion, FCPR03 increases the levels of phosphorylated AKT, GSK3β and β-catenin within the ischemic penumbra. In rats following MCAO, FCPR03 (1.25, 2.5, 5 mg/kg; i.p.) reduces the infarct volume and improves neurobehavioral outcomes.
In Vitro
FCPR03 displays at least 2100-fold selectivity over other PDEs (PDE1-3 and PDE5-11). In HT-22 cells, FCPR03 (5, 10, and 20 μM) increases cell viability under the oxygen-glucose deprivation (OGD) induced condition in a dose-dependent manner. FCPR03 (20 μM) increases the levels of phosphorylated AKT, GSK-3β, and β-catenin. FCPR03 (20 μM) protects against OGD-induced cellular apoptosis in both HT-22 cells and cortical neurons. The levels of mitochondrial membrane potential (MMP) and ROS are restored by FCPR03. FCPR03 (10 μM) shows significant protective effects.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AKT, antidepressant-like, anti-inflammatory, neuroprotective, PDE4, ischemic, inhibit, Inhibitor, GSK3β, FCPR 03, FCPR03, FCPR-03, β-catenin, Phosphodiesterase (PDE), PDE4D7, PDE4B1, stroke
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Key Properties

No computed properties available.

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FCPR03 (orb1303542)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
¥ 1,040.00
5 mg
¥ 1,690.00
1 ml x 10 mM (in DMSO)
¥ 1,820.00
10 mg
¥ 2,340.00
25 mg
¥ 3,510.00
50 mg
¥ 4,810.00
100 mg
¥ 6,370.00
200 mg
¥ 8,320.00
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