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Fedratinib hydrochloride hydrate

SKU: orb1218880

Description

Fedratinib hydrochloride hydrate is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1374744-69-0
MW615.61
Purity>98% (HPLC)
FormulaC27H40Cl2N6O4S
SMILESO=S(C1=CC=CC(NC2=NC(NC3=CC=C(OCCN4CCCC4)C=C3)=NC=C2C)=C1)(NC(C)(C)C)=O.[H]Cl.[H]Cl.[H]O[H]
TargetJAK
SolubilityDMSO:120 mg/mL (194.92 mM; Need ultrasonic);H2O:97 mg/mL (157.56 mM; Need ultrasonic)

Bioactivity

In Vivo
Animal model: C57Bl/6 mice induced by the JAK2V617F mutation. Dosage: 60 mg/kg, 120 mg/kg. Administration: Oral gavage; twice daily; for 42 days. Result: Showed a statistically significant reduction in hematocrit and leukocyte count, a dose-dependent reduction/elimination of extramedullary hematopoiesis.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TG-101348 hydrochloride hydrate | SAR 302503 hydrochloride hydrate

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  • Fedratinib hydrochloride hydrate [orb1298242]

    98.96% (May vary between batches)

    1374744-69-0

    615.61

    C27H40Cl2N6O4S

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 1 ml x 10 mM (in DMSO)
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Fedratinib hydrochloride hydrate (orb1218880)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

500 mg
5 mg
¥ 1,040.00
10 mg
¥ 1,300.00
25 mg
¥ 1,690.00
50 mg
¥ 2,080.00
100 mg
¥ 2,470.00
200 mg
¥ 3,640.00