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FGFRs-IN-1

SKU: orb2944774

Description

FGFRs-IN-1 (A16) is a potent, orally active multi-kinase inhibitor primarily targeting FGFR1-4, with additional activity against VEGFRs, Abl, and Flt3. It suppresses fibrosis-related markers like α-SMA and collagen I, inhibits TGF-β1-induced EMT in vitro, and demonstrates anti-fibrotic efficacy in mouse models of lung and liver fibrosis.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

MW537.44
FormulaC28H26Cl2N4O3
TargetFGFR,Bcr-Abl,VEGFR,FLT,Cytochromes P450

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

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Protocol Information