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Fingolimod

SKU: orb1299367

Description

Fingolimod (FTY-720) is a potent sphingosine 1-phosphate (S1P) receptor antagonist with an IC50 of 0.033 nM. It is widely used in research to investigate S1P signaling in immunology and neurology, with applications in both in vitro cell-based assays and in vivo models of autoimmune and inflammatory diseases.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Fingolimod

Key Properties

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CAS Number162359-55-9
MW307.47
Purity99.76% (May vary between batches)
FormulaC19H33NO2
SMILESCCCCCCCCc1ccc(CCC(N)(CO)CO)cc1
TargetS1P Receptor|||PAK|||LPL Receptor
SolubilityDMSO:1 mg/mL (3.25 mM);Ethanol:7.69 mg/mL (25.01 mM);Methanol:30 mg/mL (97.57 mM)

Bioactivity

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Target IC50
S1P1:0.033 nM
In Vitro
Fingolimod has been reported to reduce LPA synthesis via inhibition of the lysophospholipase autotaxin. Fingolimod treatment correlates with a significant elevation of axonal cAMP, a crucial factor for axonal outgrowth. Additionally, Fingolimod significantly reduces LPA levels in the injured nerve. PF-8380 treatment correlates with improved myelin thickness
Cell Research
Sciatic nerve crush was performed in wildtype C57BL/6, in immunodeficient Rag1 (-/-) and Foxn1 (-/-) mice. Analyses were based on walking track analysis and electrophysiology, histology, and cAMP formation. Quantification of different LPA species was performed by liquid chromatography coupled to tandem mass spectrometry. Furthermore, functional consequences of autotaxin inhibition by the specific inhibitor PF-8380 and the impact of fingolimod on early cytokine release in the injured sciatic nerve were investigated.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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p21 activated kinases, S1P Receptor, S1P, S1PReceptor, FTY 720, FTY720, FTY-720, FTY-720A, Fingolimod, Inhibitor, LPLReceptor, LPL Receptor, LPL, inhibit, PAK, Lysophospholipid Receptor

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
107970 ↗

Key Properties

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No computed properties available.

Protocol Information

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Anthony W. Frei, Ying Li, Kaiyuan Jiang, Peter Buchwald, Cherie L. Stabler Local delivery of fingolimod from three‐dimensional scaffolds impacts islet graft efficacy and microenvironment in a murine diabetic model J Tissue Eng Regen Med, 12, 2 (2017)

PubMed: 28486786

Applications

In vitro

Reactivity

Rat

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100 mg
$ 90.00
500 mg
$ 170.00
1 g
$ 200.00
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