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Flonoltinib

SKU: orb1709375

Description

JAK2/FLT3-IN-1

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number2387765-27-5
MW467.58
Purity99.52%
FormulaC25H34FN7O
SMILESFC1=CC(=CC=C1N2CCC(N(C)CCO)CC2)NC=3N=CC(=C(N3)C=4C=NN(C4)C(C)C)C
TargetApoptosis,FLT,JAK
SolubilityDMSO:20 mg/mL (42.77 mM);10% DMSO+90% Saline:2 mg/mL (4.28 mM)

Bioactivity

Target IC50
JAK3:39 nM|FLT3:4 nM|JAK1:26 nM|JAK2:0.7 nM
In Vivo
Flonoltinib exhibits significant antitumor effects and the tumor growth inhibitory rates (TGI) were respective 58% and 93% in the MV4-11-bearing mice model.
In Vitro
Flonoltinib (0.005-0.1 μM; for 2 hours) has a dose-dependent effect on the induction of apoptosis in the MV4-11 cells. Flonoltinib (0.008-1 μM; for 2 hours) down-regulates p-FLT3 in a dose-dependent manner from 0.008 to 1 μM. Flonoltinib (0.005-0.1 μM; for 2 hours) strongly induces cell cycle arrest with a G1/G0 percentage of 85% at 100 nM in the MV4-11 cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JAK3, JAK2, JAK2/FLT3 IN 1, JAK2/FLT3IN1, JAK-2/FLT3-IN-1, JAK2/FLT3-IN-1, JAK1, FLT3

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Key Properties

No computed properties available.

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Flonoltinib (orb1709375)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,430.00
5 mg
¥ 2,210.00
1 ml x 10 mM (in DMSO)
¥ 2,340.00
10 mg
¥ 3,120.00
25 mg
¥ 4,680.00
50 mg
¥ 7,280.00
DispatchUsually dispatched within 6-8 weeks
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