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Flumethasone

SKU: orb1309688

Description

Flumethasone (RS-2177) is a synthetic glucocorticoid receptor agonist used in research for its potent anti-inflammatory, antipruritic, and vasoconstrictive effects. It is applied in pharmacological studies to investigate corticosteroid signaling and related pathways in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research

Images & Validation

Key Properties

CAS Number2135-17-3
MW410.45
Purity99.96%
FormulaC22H28F2O5
SMILES[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
TargetGlucocorticoid Receptor,Antifungal,Interleukin,Nrf2,TNF
SolubilityDMSO:55 mg/mL (134 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.87 mM);Ethanol:6 mg/mL (14.62 mM)

Bioactivity

In Vitro
Flumethasone (5 mg) increased plasma glucose concentrations, decreased serum β-hydroxybutyric acid and urinary acetoacetate concentrations, and ameliorated uterine disease in calves with ketosis. In calves with severe acute bronchopneumonia, Flumethasone in combination with ceftiofur sodium returned physiologic parameters to normal levels and improved survival.

Storage & Handling

Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, NSC 54702, NSC54702, NSC-54702, Inhibitor, Flumetasone, Flumethasone, GlucocorticoidReceptor, Glucocorticoid Receptor, RS 2177, RS2177, RS-2177

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Flumethasone (orb1309688)

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% Tween 80 +
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Available Sizes

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1 ml x 10 mM (in DMSO)
¥ 910.00
50 mg
¥ 910.00
100 mg
¥ 1,300.00
DispatchUsually dispatched within 3-5 working days
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