Fosbretabulin disodium

SKU: orb1225970

Description

A derivative of combretastatin that acts as a microtubule destabilising agent; damage the vasculature (blood vessels) of cancer tumours causing central necrosis.Chemotherapeutic Agents Phase 3 Clinical(In Vitro):Fosbretabulin disodium inhibits growth of leukemia P-388, pancreas BXPC-3, neuroblast SK-N-SH, thyroid SW1736, lung-NSC NCI-H460, prostate DU-145, an pharynx FADU, with EC50s of 0.0029, 0.23, 0.00025, 0.00061, 0.00035, 0.00072, and 0.00045 μg/mL, respectively.(In Vivo):Fosbretabulin disodium (100 mg/kg; i.p.) increases the mean arterial blood pressure (MABP) at 1 and 6 h after administration and decreases the tumor blood flow in rats.

Images & Validation

−

Key Properties

−

CAS Number	168555-66-6
MW	440.292
Purity	>98% (HPLC)
Formula	C₁₈H₁₉Na₂O₈P
SMILES	COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+]
Target	Microtubule/Tubulin
Solubility	H2O: 4.4 mg/mL (Need ultrasonic and warming); DMSO: < 0.044 mg/mL

Bioactivity

−

In Vivo	Animal model: Male BD9 rats (7-9 weeks) bearing the s. c. implanted P22 tumor. Dosage: 100 mg/kg. Administration: A single i.p. injections. Result: Significantly raised the MABP by about 30%, and reduced the heart rate at 1 h after administration. Reduced the blood flow in the tumor. Read more...

Storage & Handling

−

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

CA4DP | CA4P | Combretastatin A-4 phosphate

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol

Microtubule/Tubulin

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols