Frataxin Antibody / FXN

SKU: orb639667

Description

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), a human autosomal recessive neurodegenerative disease. Lack of Frataxin causes iron to accumulate in the mitochondrial matrix suggesting that Frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport. Frataxin has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.

Images & Validation

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Tested Applications	ELISA
Dilution range	ELISA (order BSA-free format for coating)
Reactivity	Human
Application Notes	Optimal dilution of the antibody should be determined by the researcher.

Key Properties

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Antibody Type	Primary Antibody
Host	Mouse
Clonality	Recombinant
Isotype	Mouse IgG1, kappa
Clone No.	rFXN/2124
Immunogen	Amino acids 57-210 from the human protein were used as the immunogen for this FXN antibody.
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Disclaimer	For research use only

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SDS-PAGE analysis of purified, BSA-free recombinant FXN antibody (clone rFXN/2124) as confirmation of integrity and purity.

Quick Database Links

UniProt

Q16595

UniProt Details

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No UniProt data available

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Protocol Information

ELISA

Enzyme-linked Immunosorbent Assay (EIA)

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