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FTBMT

SKU: orb1308289

Description

FTBMT is a potent and selective GPR52 agonist with an EC50 of 75 nM. It exhibits antipsychotic and cognitive-enhancing properties, making it a valuable research tool for investigating neuropsychiatric disorders in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1358575-02-6
MW392.35
Purity98.00% (May vary between batches)
FormulaC19H16F4N4O
SMILESCc1nc(Cc2cc(F)cc(c2)C(F)(F)F)nn1-c1ccc(C(N)=O)c(C)c1
TargetGPCR
SolubilityDMSO:45 mg/mL (114.69 mM);H2O:< 0.1 mg/mL (insoluble);10% DMSO+90% Corn Oil:2 mg/mL (5.1 mM)

Bioactivity

Target IC50
GPR52:75 nM(EC50)
In Vivo
In rats, FTBMT (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory. FTBMT (30 mg/kg, 90 minutes) shows antipsychotic-like activity without causing catalepsy in mice
In Vitro
In CHO cells expressing human, mouse, or rat GPR52, FTBMT (0.1-10 μM) improves intracellular cAMP levels (pEC50s of 7.03, 6.85, and 6.87, respectively).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, FTBMT, GPR52, inhibit
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 90.00
5 mg
$ 90.00
10 mg
$ 120.00
25 mg
$ 220.00
50 mg
$ 360.00
100 mg
$ 540.00
200 mg
$ 700.00
DispatchUsually dispatched within 3-5 working days
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