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FTX-6746

SKU: orb1744203

Description

FTX-6746 is a selective, orally bioavailable reverse agonist of PPARG with demonstrated anticancer properties. It has shown research utility in models of urothelial carcinoma, exhibiting activity in both in vitro cellular assays and in vivo tumor studies.

Research Area

Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number2829349-96-2
MW316.69
Purity98.68%
FormulaC16H7ClF2N2O
SMILESN#CC=1C=CC(Cl)=C(C1)C2=CC(=O)C=3C(F)=CC(F)=CC3N2
TargetPPAR
SolubilityDMSO:30 mg/mL (94.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.32 mM)

Bioactivity

In Vivo
In mouse UMUC9 or HT1197 xenograft models, FTX-6746 significantly inhibited tumor growth by oral administration (doses of 3-60 mg/kg twice daily for 21 days).

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

FTX6746, FX 909, FX909
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

FTX-6746 (orb1744203)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% Tween 80 +
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1 mg
¥ 3,120.00
DispatchUsually dispatched within 6-8 weeks
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