FTY720 (S)-Phosphate

SKU: orb1707289

Description

FTY720 (S)-Phosphate is the active metabolite of FTY720, functioning as a potent S1P receptor agonist. It induces lymphocyte sequestration and enhances endothelial barrier function, making it a key research tool for studying autoimmune diseases, cancer, and vascular biology in both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	402616-26-6
MW	387.45
Purity	99.37%
Formula	C₁₉H₃₄NO₅P
SMILES	C(C[C@@](COP(=O)(O)O)(CO)N)C1=CC=C(CCCCCCCC)C=C1
Target	S1P Receptor,LPL Receptor
Solubility	H2O:< 1 mg/mL (insoluble);DMSO:0.5 mg/mL (slightly soluble)

Bioactivity

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In Vivo

FTY720 (S)-Phosphate (0.5 mg/kg, intraperitoneal injection) maintained the expression level of S1PR1 in mouse lung tissue, exerted protective effects against bleomycin-induced acute lung injury (ALI), and reduced the degree of leukocyte infiltration in the lung tissue of bleomycin-injured model mice .

Storage & Handling

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Storage	The compound is unstable in solution. Please use soon \| Powder: -20°C for 3 years \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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(S)-FTY720 phosphate, (S)-FTY720P, FTY 720 Phosphate, FTY720 (S) Phosphate, FTY720 (S)Phosphate, FTY-720 (S)-Phosphate, FTY720 Phosphate, FTY-720 Phosphate, FTY720P, S1PR1

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Compound Identifiers

PubChem CID

11452022 ↗

Key Properties

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No computed properties available.

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