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Galectin-3-IN-6

SKU: orb3028670

Description

Galectin-3-IN-6 (Compound 12) is an orally active galectin-3 (Gal-3) inhibitor, with an IC50 of 12 nM and a Kd of 13 nM for Gal-3. In a CCl4-induced mouse model of acute liver injury and fibrosis, Galectin-3-IN-6 significantly reduces fibrosis markers collagen-1 and α-smooth muscle actin (αSMA) by 64% and 71%, respectively, demonstrating notable anti-fibrotic activity. Galectin-3-IN-6 is applicable for research in fibrosis-related diseases, cancer, and cardiovascular disorders.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2604662-64-6
MW645.454
FormulaC28H29Cl2F3N4O6
SMILESO(C)[C@@H]1[C@H]([C@@H](O)[C@@H](CO)O[C@H]1C(N(C2=CC(Cl)=CC(Cl)=C2)[C@@H]3[C@@H](O)CCCC3)=O)N4C=C(N=N4)C5=CC(F)=C(F)C(F)=C5
TargetGalectin

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

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Protocol Information