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GED-0507-34 Levo

SKU: orb2814927

Description

GED-0507-34 Levo is an orally active PPARγ modulator that attenuates intestinal fibrosis by suppressing key pro-fibrotic pathways. It downregulates expression of Acta2, COL1a1, Fn1, α-SMA, collagen, and TGFβ/Smad components, and inhibits TGF-β-driven activation in both fibroblast and intestinal epithelial cell lines in vitro.

Research Area

Immunology & Inflammation, Metabolism Research, Molecular Biology, Stem Cell & Developmental Biology

Images & Validation

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GED-0507-34 Levo

Key Properties

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CAS Number921195-93-9
MW195.22
Purity98.19% (May vary between batches)
FormulaC10H13NO3
SMILESC([C@@H](C(O)=O)OC)C1=CC=C(N)C=C1
TargetPPAR,Interleukin,TGF-beta/Smad

Bioactivity

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In Vivo
C57BL/6 mice (n = 110) were administered 2.5% DSS in drinking water (3 cycles over 6 weeks) to induce intestinal fibrosis, and treated daily with GED-0507-34 Levo (30 mg/kg/d; oral). Fibrosis severity was evaluated via macroscopic/histological scores and fibrosis marker expression. GED-0507-34 Levo treatment alleviated intestinal fibrosis.
In Vitro
GED-0507-34 Levo was added to TGF-β–stimulated intestinal fibroblasts, epithelial cell lines, and primary fibroblasts from ulcerative colitis patients. Expression of α-SMA, Fn1, TGF-β, ACTA1, and epithelial markers was assessed. GED-0507-34 Levo inhibited TGF-β–induced fibrotic activation.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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(S)-3-(4-Aminophenyl)-2-methoxypropanoic acid, (S)-3-(4-Aminophenyl)-2-methoxypropanoicacid, Y4H78S56YZ
Quality Guarantee

Quality Guarantee

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Compound Identifiers

PubChem CID
67008033 ↗

Key Properties

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No computed properties available.

Protocol Information

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1 mg
$ 240.00
5 mg
$ 530.00
10 mg
$ 740.00
25 mg
$ 1,120.00
50 mg
$ 1,530.00
100 mg
$ 2,010.00
200 mg
$ 2,730.00
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