Gemifioxacin mesylate

SKU: orb1225691

Description

Gemifloxacin mesylate is an oral broad-spectrum quinolone antibacterial agent, used in the treatment of acute bacterial exacerbation of chronic bronchitis, and mild-to-moderate pneumonia.(In Vitro):Gemifloxacin has higher antibacterial activity than Moxifloxacin (HY-66011A) against Streptococcus pneumoniae with a MIC90 of 0.06 μg/mL.Gemifloxacin has highly potent antibacterial activity against Penicillin-resistant strains of S. pneumoniae with a MIC90 of 0.03 μg/mL.(In Vivo):Gemifloxacin has favorable pharmacokinetic profile in animals after oral administration.

Images & Validation

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Key Properties

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CAS Number	210353-53-0
MW	485.49
Purity	>98% (HPLC)
Formula	C₁₉H₂₄FN₅O₇S
SMILES	CO/N=C/1\CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F.CS(=O)(=O)O
Target	DNA gyrase
Solubility	DMSO: 30mg/mL

Bioactivity

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In Vivo	Gemifloxacin has favorable pharmacokinetic profile in animals after oral administration. Pharmacokinetic Parameters of Gemifloxacin in Sprague-Dawley rats and dogs. Read more...
In Vitro	Gemifloxacin has higher antibacterial activity than Moxifloxacin (HY-66011A) against Streptococcus pneumoniae with a MIC90 of 0.06 μg/mL. Gemifloxacin has highly potent antibacterial activity against Penicillin-resistant strains of S. pneumoniae with a MIC90 of 0.03 μg/mL. Read more...

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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LB 20304a | SB 265805S

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Gene Symbol

DNA gyrase

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