Germacrone

SKU: orb1304815

Description

Germacrone, a sesquiterpene isolated from Curcuma zedoaria, exhibits anti-inflammatory, anti-androgenic, and antiviral properties. It has been shown in vitro to induce apoptosis and inhibit proliferation in glioma cells, supporting its investigation in oncology and inflammation-related research.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	6902-91-6
MW	218.33
Purity	99.95% (May vary between batches)
Formula	C₁₅H₂₂O
SMILES	CC(C)=C1C\C=C(C)/CC\C=C(C)/CC1=O
Target	Influenza Virus,Antiviral,Reductase,NF-κB,Apoptosis,Cytochromes P450,Dehydrogenase,Nrf2
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.58 mM);DMSO:2.19 mg/mL (10.03 mM)

Bioactivity

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In Vivo

Germacrone shows antiviral activity against the H1N1 and H3N2 influenza A viruses and the influenza B virus in a dose-dependent manner, exerts an effective protection of mice from lethal infection and reduces the virus titres in the lung.

In Vitro

Germacrone can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway. Germacrone might be a new potent chemopreventive drug candidate for liver cancer via regulating the expression of proteins related to G2/M cell cycle and apoptosis, and p53 and oxidative damage may play important roles in the inhibition of human hepatoma cells growth by germacrone. Germacrone moderately inhibits CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 uM, and produces two oxidized metabolites and four glutathione conjugates.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Antiviral, CYP2B6, CYP3A4, Inhibitor, Germacrone, inhibit, Influenza Virus, InfluenzaVirus

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Compound Identifiers

PubChem CID

5317571 ↗

Key Properties

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No computed properties available.

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Germacrone (orb1304815)

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CAS Number:	32663-51-7
MW:	218.33
Formula:	C₁₅H₂₂O

CAS Number:	92691-35-5
MW:	234.33
Formula:	C₁₅H₂₂O₂

Purity:	>98% (HPLC)
CAS Number:	6902-91-6
MW:	218.2
Formula:	C₁₅H₂₂O

Purity:	>98% (HPLC)
CAS Number:	70629-66-2

Germacrone

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Germacrone (orb1304815)

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