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GLPG0634 analog

SKU: orb1304565

Description

GLPG0634 analog

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1206101-20-3
MW410.43
Purity99.22%
FormulaC23H18N6O2
SMILESO=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)C#N)cc3)n2n1)C1CC1
TargetJAK,Tyrosine Kinases
SolubilityDMSO:7.5 mg/mL (18.27 mM)

Bioactivity

Target IC50
TYK2:116 nM|JAK2:2 nM|JAK1:1 nM|JAK3:81 nM
In Vivo
In multiple cell lines, GLPG0634 inhibited IFN-αB2-induced JAK1/TYK2 type II receptor signaling and IL-2/4-induced JAK1/JAK3/γc signaling IC50 150-760 nM). A the cellular level, GLPG0634 was more Selective for JAK1-containing JAK/STAT signaling than JAK2 kinase. In addition, GLPG0634 inhibite the proliferation of Th1/Th2/Th17 cells.
In Vitro
In multiple cell lines, GLPG0634 inhibited IFN-αB2-induced JAK1/TYK2 type II receptor signaling and IL-2/4-induced JAK1/JAK3/γc signaling IC50 150-760 nM). A the cellular level, GLPG0634 was more Selective for JAK1-containing JAK/STAT signaling than JAK2 kinase. In addition, GLPG0634 inhibite the proliferation of Th1/Th2/Th17 cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AK-STAT, Inhibitor, inhibit, Janus kinase, JAK3, JAK2, JAK, JAK1, OSM/IL-lβ, Hela cell, GLPG0634 analog, GLPG-0634 analog, GLPG0634 analogue, GLPG 0634, GLPG0634, GLPG-0634, TYK2, TyrosineKinases, Tyrosine Kinases

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Key Properties

No computed properties available.

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GLPG0634 analog (orb1304565)

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Available Sizes

Select a size below

1 mg
¥ 1,040.00
2 mg
¥ 1,170.00
5 mg
¥ 1,560.00
1 ml x 10 mM (in DMSO)
¥ 1,690.00
10 mg
¥ 2,470.00
25 mg
¥ 4,160.00
50 mg
¥ 6,890.00
100 mg
¥ 9,620.00
500 mg
¥ 19,370.00
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