Glyco-Obeticholic acid

SKU: orb1309625

Description

Glyco-Obeticholic acid is the active metabolite of the FXR agonist Obeticholic acid. This small molecule is used in research to investigate FXR signaling in metabolic and liver diseases, employing both in vitro assays and in vivo models.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	863239-60-5
MW	477.68
Purity	99.95% (May vary between batches)
Formula	C₂₈H₄₇NO₅
SMILES	C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCC(NCC(O)=O)=O)C)(CC4)[H])[H])([C@H](O)[C@H](CC)[C@@]1(C[C@H](O)CC2)[H])[H])[H]
Target	FXR
Solubility	DMSO:50 mg/mL (104.67 mM)

Bioactivity

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In Vitro	In the liver, obeticholic acid undergoes conjugation with glycine to produce glyco-obeticholic acid, subsequently secreted into bile. Upon reaching the ileum and colon, microorganisms deconjugate this compound back into its original form, obeticholic acid, facilitating its reabsorption or fecal excretion. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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colon, Glyco Obeticholic acid, GlycoObeticholic acid, Glyco-Obeticholic acid, FXR, metabolite,liver, microorganisms, Inhibitor, inhibit, NR1H4, ileum

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Compound Identifiers

PubChem CID

121322333 ↗

Key Properties

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No computed properties available.

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