Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

Glyco-Obeticholic acid

SKU: orb1309625

Description

Glyco-Obeticholic acid is the active metabolite of the FXR agonist Obeticholic acid. This small molecule is used in research to investigate FXR signaling in metabolic and liver diseases, employing both in vitro assays and in vivo models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number863239-60-5
MW477.68
Purity99.77% (May vary between batches)
FormulaC28H47NO5
SMILESC[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCC(NCC(O)=O)=O)C)(CC4)[H])[H])([C@H](O)[C@H](CC)[C@@]1(C[C@H](O)CC2)[H])[H])[H]
TargetFXR
SolubilityDMSO:50 mg/mL (104.67 mM)

Bioactivity

In Vitro
In the liver, obeticholic acid undergoes conjugation with glycine to produce glyco-obeticholic acid, subsequently secreted into bile. Upon reaching the ileum and colon, microorganisms deconjugate this compound back into its original form, obeticholic acid, facilitating its reabsorption or fecal excretion.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

colon, Glyco Obeticholic acid, GlycoObeticholic acid, Glyco-Obeticholic acid, FXR, metabolite,liver, microorganisms, Inhibitor, inhibit, NR1H4, ileum

Similar Products

  • Glyco-Obeticholic acid [orb1217577]

    >98% (HPLC)

    863239-60-5

    477.68

    C28H47NO5

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 90.00
2 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 160.00
5 mg
$ 160.00
10 mg
$ 220.00
25 mg
$ 390.00