Glycolithocholic acid 3-sulfate

SKU: orb1983478

Description

Glycolithocholic acid 3-sulfate (SLCG) is a sulfated bile acid metabolite derived from glycocholic acid. It has been shown to selectively inhibit HIV-1 replication in vitro, making it a compound of interest for virology and antiviral research, particularly in studying host-pathogen interactions and novel therapeutic mechanisms.

Research Area

Infectious Disease & Virology, Metabolism Research, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	15324-64-8
MW	513.69
Purity	99.00% (May vary between batches)
Formula	C₂₆H₄₃NO₇S
SMILES	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](OS(=O)(=O)O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(NCC(O)=O)=O)C)[H])[H]
Target	HIV Protease,Endogenous Metabolite
Solubility	DMSO:3 mg/mL (5.84 mM)

Bioactivity

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In Vitro	Glycolithocholic acid 3-sulfate (100 μg/ml) fully protected MT-4 cells from HIV-1-induced cellular pathogenicity, while no toxicity to host cells was observed at concentrations of 200 μg/ml. Glycolithocholic acid 3-sulfate inhibited the expression of HIV-1 antigen in HIV-1-infected CEM cells. Read more...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Glycolithocholate sulfate, SLCG, Sulfolithocholylglycine

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Compound Identifiers

PubChem CID

72222 ↗

Key Properties

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No computed properties available.

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