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GNE-900

SKU: orb1738221

Description

GNE-900 is a potent, selective, and orally bioavailable ATP-competitive inhibitor of ChK1 (IC50=1.1 nM) over ChK2. It enhances DNA damage-induced cell death and demonstrates antitumor activity in preclinical models, making it a valuable tool for studying DNA damage response and oncology research.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number1200126-26-6
MW367.45
Purity99.20% (May vary between batches)
FormulaC23H21N5
SMILESC(#N)C=1C=C2C=3C(NC2=CN1)=NC=C(C3)C4=CC=C(CN5CCCCC5)C=C4
TargetChk,Apoptosis
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.72 mM);DMSO:3.85 mg/mL (10.48 mM)

Bioactivity

Target IC50
Chk1:0.0011 μM|Chk2:1.5 μM
In Vivo
GNE-900 (2.5-40 mg/kg, p.o., once; Sprague-Dawley rats) combined with gemcitabine (120 mg/kg) reduced tumor volume and increased DNA damage and γ-H2AX expression levels in rats.
In Vitro
GNE-900 (1 µM; 1-48 h; HT-29 cells) induces apoptosis and enhances cleaved PARP expression when combined with gemcitabine (50 nM) in HT-29 cells.

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Chk1, Apoptosis, GNE 900, GNE900, GNE-900, Omeprazole acid
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

GNE-900 (orb1738221)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
¥ 1,170.00
5 mg
¥ 1,820.00
10 mg
¥ 2,600.00
25 mg
¥ 4,160.00
50 mg
¥ 5,980.00
100 mg
¥ 8,840.00
200 mg
¥ 11,960.00
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