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Golidocitinib

SKU: orb1309956

Description

Golidocitinib (AZD4205) is a potent and selective JAK1 inhibitor with an IC50 of 73 nM, demonstrating minimal activity against JAK2 and JAK3. It is a valuable research tool for investigating JAK/STAT signaling in immunological and inflammatory diseases, with utility in both in vitro and in vivo experimental models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number2091134-68-6
MW489.57
Purity99.98%
FormulaC25H31N9O2
SMILESCOc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12
TargetJAK
SolubilityDMSO:250 mg/mL (510.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.21 mM)

Bioactivity

Target IC50
JAK1:73 nM
In Vivo
AZD4205, administered orally at doses of 12.5 mg/kg, 25 mg/kg, or 50 mg/kg twice daily (BID), exhibits dose-dependent antitumor effects when used alone. Additionally, it boosts the antitumor efficacy of osimertinib when compared to the administration of osimertinib alone in mice implanted with NCI-H1975 cells.
In Vitro
AZD4205 significantly inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50: 161 nM).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AZD 4205, AZD4205, AZD-4205, Golidocitinib, Inhibitor, inhibit, Janus kinase, JAK, JAK1
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Golidocitinib (orb1309956)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
5 mg
¥ 1,820.00
1 ml x 10 mM (in DMSO)
¥ 1,950.00
10 mg
¥ 2,600.00
25 mg
¥ 4,160.00
50 mg
¥ 6,110.00
100 mg
¥ 9,360.00
DispatchUsually dispatched within 3-5 working days
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