GPR120 Agonist 3

SKU: orb1308260

Description

GPR120-IN-1 is a selective GPR120 agonist with a logEC50 of -7.62. This compound is a valuable research tool for investigating the role of GPR120 in metabolic and inflammatory processes, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1599477-75-4
MW	405.84
Purity	99.29%
Formula	C₁₉H₂₃ClF₃NO₃
SMILES	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Target	GPCR
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.93 mM);DMSO:50 mg/mL (123.2 mM);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

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Target IC50	GPR120:−7.62 (logEC50)
In Vivo	GPR120-IN-1 treatment has beneficial effects on hepatic lipid metabolism. It causes decreased liver triglycerides, decreased hepatic steatosis, and DAGs, as well as decreased saturated free fatty acid content. GPR120-IN-1 causes improved insulin sensitivity with increased glucose infusion rates. It also enhanced the insulin stimulated-glucose disposal rate. Only in WT mice, along with a marked increase in the ability of insulin to suppress hepatic glucose production. Read more...
In Vitro	GPR120-IN-1 causes a concentration-dependent response to recruiting β-arrestin-2 in both human and mouse Gpr120 expressing cells(EC50s: ~0.35 μM). GPR120-IN-1 produces concentration-dependent increases in IP3 production from both human and mouse Gpr120 expressing cells. GPR120-IN-1 strongly and comparably inhibits LPS-induced phosphorylation of Ikkβ, Tak1, and Jnk and blocked IκB degradation. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, logEC50, Inhibitor, FFAR, Free Fatty Acid Receptor, GPR120-IN-1, GPR120, GPR120 Agonist 3, GPR-120 Agonist 3

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Compound Identifiers

PubChem CID

73777063 ↗

Key Properties

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No computed properties available.

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GPR120 Agonist 3 (orb1308260)

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CAS Number:	1390641-90-3
MW:	499.59
Formula:	C₂₇H₃₀FNO₅S

CAS Number:	1628641-89-3
MW:	459.79
Formula:	C₂₁H₁₅ClF₅NO₃

CAS Number:	1374259-84-3
MW:	405.596
Formula:	C₂₁H₃₄KO₅

GPR120 Agonist 3

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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GPR120 Agonist 3 (orb1308260)

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