Gramicidin

SKU: orb1309668

Description

Gramicidin is an antimicrobial peptide that forms ion channels in cell membranes, disrupting ionic gradients and killing cells. It is widely used in research on membrane biophysics, ion transport mechanisms, and as a tool compound in both in vitro and in vivo studies of bacterial cytotoxicity and channel function.

Research Area

Immunology & Inflammation, Infectious Disease & Virology

Images & Validation

−

Key Properties

−

CAS Number	1405-97-6
MW	1882.33
Purity	96.40% (May vary between batches)
Formula	C₉₉H₁₄₀N₂₀O₁₇
SMILES	C[C@@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC5=CNC6=CC=CC=C65)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC7=CNC8=CC=CC=C87)C(=O)NCCO)NC(=O)CNC(=O)[C@H](C(C)C)NC=O
Target	Antibiotic,Antibacterial,MRP
Solubility	DMSO:50 mg/mL (26.56 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.06 mM)

Bioactivity

−

In Vivo

METHODS: To study the effect on in vivo allograft survival, Gramicidin (2-4 mg/kg) was injected intraperitoneally into ectopic heart transplanted rats once daily for 6 days. RESULTS: Graft pulsation in the control group ceased at 5.4+/-0.4 days post-transplantation due to acute allograft rejection, whereas recipients in the group receiving intraperitoneal injections of Gramicidin (2-4 mg/kg) had a significant prolongation of graft pulsation to 15.4+/-4.3 or 18.4+/-3.9 days post-transplantation, respectively.

In Vitro

METHODS: OC cells OVCAR8, A2780 and SKOV3 were treated with Gramicidin (0.33-3 µM) for 24-72 h. Cell viability was measured by WST-1 assay. RESULTS: Gramicidin inhibited the growth of OC cells in a dose- and time-dependent manner, with IC50 values of 0.0763, 0.1856 and 0.1148 µM for OVCAR8, SKOV3 and A2780 cells, respectively, at 72 h. METHODS: Human gastric cancer cells SGC-7901 were treated with Gramicidin (0.3-3 µM) for 24-48 h. Apoptosis was detected by Flow cytometry. RESULTS: Gramicidin promoted apoptosis in SGC-7901 cells in a time- and dose-dependent manner. When cells were incubated with Gramicidin for 48 h, the percentage of viable cells decreased to 54.2% with 3 µM Gramicidin treatment compared to control.

Storage & Handling

−

Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Antibiotic, Bacterial, MRP1, inhibit, Inhibitor, Gramicidin, Gramicidina, Gramicidine, Gramicidinum

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

16130140 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Gramicidin (orb1309668)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

Purity:	0.98
CAS Number:	113-73-5
MW:	1369.52
Formula:	C₆₄H₉₄F₆N₁₂O₁₄

Purity:	96.65% (May vary between batches)
CAS Number:	1257-08-5
MW:	442.37
Formula:	C₂₂H₁₈O₁₀

CAS Number:	11029-61-1
MW:	1882.29
Formula:	C₉₉H₁₄₀N₂₀O₁₇

CAS Number:	15207-30-4
MW:	1214.37
Formula:	C₆₀H₉₄Cl₂N₁₂O₁₀

Gramicidin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Gramicidin S [orb1785886]

(-)-Epicatechin gallate [orb1305097]

Gramicidin C [orb1690159]

Gramicidin A [orb1693737]

Gramicidin S 2HCl [orb2813979]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Gramicidin (orb1309668)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors