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GRL-190-21

SKU: orb2566159

Description

GRL-190-21 (compound 5e) is a potent and selective SARS-CoV-2 main protease (Mpro) inhibitor, exhibiting sub-nanomolar enzyme affinity (K_i = 0.04 nM) and antiviral activity (EC_50 = 0.26 µM) in VeroE6 cells. It effectively suppresses viral replication and cytopathic effects in vitro, serving as a valuable tool compound for research into coronavirus pathogenesis and antiviral drug discovery.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number2755957-14-1
MW513.55
FormulaC24H34F3N5O4
SMILESC(N[C@@H](C[C@H]1C(=O)NCCC1)C#N)(=O)[C@@H]2[C@@]3([C@@](C3(C)C)(CN2C([C@@H](NC(C(F)(F)F)=O)[C@@](C)(C)C)=O)[H])[H]
TargetSARS-CoV

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information