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GSK321

SKU: orb1697047

Description

GSK321 is a potent and selective mutant IDH1 inhibitor. It suppresses lipid synthesis and cell proliferation in OPA1-deficient MEFs, while also inhibiting cytoplasmic glutamine reductive carboxylation. This compound is a valuable research tool for studying metabolic dysregulation in cancers such as leukemia, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1816331-63-1
MW501.55
Purity99.73% (May vary between batches)
FormulaC28H28FN5O3
SMILESC(N1C2=C(C(C(NC3=CC([C@H](C)O)=CC=C3)=O)=N1)CN(C(=O)C4=CC=CN4)C[C@H]2C)C5=CC=C(F)C=C5
TargetDehydrogenase,Isocitrate Dehydrogenase (IDH)
SolubilityDMSO:200 mg/mL (398.76 mM)

Bioactivity

In Vitro
METHODS: R132G IDH1 AML cells were treated with GSK321 (0.01-10 μM) and the intracellular 2-HG level was observed. RESULTS: The intracellular 2-HG level decreased in a concentration-dependent manner, with an inhibition rate of 78% at a GSK321 concentration of 1.7 μM.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

IDH1, GSK 321, GSK321, GSK-321

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Key Properties

No computed properties available.

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GSK321 (orb1697047)

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2 mg
¥ 2,470.00
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