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GSK854

SKU: orb1703405

Description

GSK854 is a potent and selective TNNI3K inhibitor. It reduces oxidative stress and limits cardiomyocyte pyroptosis and apoptosis following myocardial infarction in mice, thereby attenuating adverse cardiac remodeling. This small molecule is a valuable research tool for studying ischemic heart disease in both in vitro and in vivo models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number1316059-00-3
MW482.96
Purity98.91% (May vary between batches)
FormulaC18H19ClN6O4S2
SMILESCCS(=O)(=O)c1ccc(cc1Nc1cc(Nc2ccc(Cl)cn2)ncn1)S(=O)(=O)NC
TargetApoptosis,Others,MAPK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.28 mM);DMSO:100 mg/mL (207.06 mM)

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, GSK 854, GSK854, GSK-854, TNNI3 Interacting Kinase (TNNI3K)
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

GSK854 (orb1703405)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

1 mg
¥ 1,820.00
5 mg
¥ 3,770.00
1 ml x 10 mM (in DMSO)
¥ 4,160.00
10 mg
¥ 5,720.00
25 mg
¥ 10,790.00
50 mg
¥ 15,860.00
100 mg
¥ 24,830.00
500 mg
¥ 49,270.00
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