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GW 833972A

SKU: orb1745232

Description

GW 833972A is a selective CB2 receptor agonist that inhibits induced neural depolarization and citric acid-induced cough in an animal model.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1092502-33-4
MW444.24
Purity99.97%
FormulaC18H14Cl2F3N5O
SMILESCl.O=C(NCC=1C=CN=CC1)C2=CN=C(N=C2C(F)(F)F)NC=3C=CC=C(Cl)C3
TargetCannabinoid Receptor
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (4.5 mM);DMSO:27.5 mg/mL (61.9 mM)

Bioactivity

Target IC50
CB2 receptor (rat):7.5 (pEC50)|CB2 receptor (human):7.3 (pEC50)
In Vivo
GW 833972A (30 mg/kg, 2 mL/kg; intraperitoneal injection; single dose, administered 30 minutes before the experiment) inhibits conscious cough symptoms induced by citric acid in guinea pigs and reduces main bronchial blood protein exudation caused by Capsaicin.
In Vitro
GW 833972A (0.3-300 μ M; 10 min) inhibited Capsaicin induced Depolarization of human and guinea pigs, and also inhibited Prostaglandin E (2) and hypertonic saline induced Depolarization of isolated guinea pig Vagus nerve nerve.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Cannabinoid Receptor, CannabinoidReceptor, GW833972A, GW 833972A

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Key Properties

No computed properties available.

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GW 833972A (orb1745232)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,690.00
1 ml x 10 mM (in DMSO)
¥ 2,730.00
5 mg
¥ 2,860.00
10 mg
¥ 4,160.00
25 mg
¥ 8,060.00
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