Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

GW788388

SKU: orb1225025

Description

A potent, selective, and orally active TGF-β type I receptor (ALK5) inhibitor with IC50 of 18 nM in binding assay; displays excellent selectivity over a panel of kinases (AMPK, Chk1, PDK1, etc.); has an IC50 of 93 nM in TGF-β cellular assay; presents activity in a PAN-induced model of kidney fibrosis by inhibiting collagen IA1 mRNA at doses of 3 and 10 mg/kg u.i.d.

Images & Validation

Key Properties

CAS Number452342-67-5
MW425.4824
Purity>98% (HPLC)
FormulaC25H23N5O2
SMILESO=C(NC1CCOCC1)C2=CC=C(C3=NC=CC(C4=CNN=C4C5=NC=CC=C5)=C3)C=C2
TargetTGFBR
SolubilityDMSO: ≥ 48 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GW 788388 | GW-788388

Similar Products

  • GW788388 [orb1307416]

    >98%

    452342-67-5

    425.5

    C25H23N5O2

    25 mg, 5 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

GW788388 (orb1225025)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
¥ 1,430.00
10 mg
¥ 2,080.00
25 mg
¥ 3,250.00
50 mg
¥ 5,070.00
100 mg
¥ 7,280.00
500 mg
¥ 16,380.00