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GW806742X

SKU: orb1309591

Description

GW806742X

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number579515-63-2
MW573.55
Purity99.07% (May vary between batches)
FormulaC25H22F3N7O4S
SMILESCN(c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1)c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1
TargetMLK|||VEGFR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.97 mM);DMSO:125 mg/mL (217.94 mM)

Bioactivity

Target IC50
VEGFR2:2 nM|MLKL:9.3 μM (Kd)
In Vitro
GW806742X (1 μM) retards MLKL translocation to the membrane.GW806742X (0.1-10000 nM) rescues 50% of wild-type mouse dermal fibroblasts (MDFs) from TSQ-induced necroptosis with an IC50< 50 nM when 1 ng/mL TNF is used.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

membrane, Inhibitor, GW806742X, GW-806742X, HUVEC, death, necroptotic, MLKs, MLKL, Mixed Lineage Kinase, inhibit, VEGFR, VEGFR2, Vascular endothelial growth factor receptor, TSQ, translocation
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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2 mg
$ 70.00
5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 110.00
25 mg
$ 170.00
50 mg
$ 240.00
100 mg
$ 410.00
DispatchUsually dispatched within 3-5 working days
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