GYKI 52466 dihydrochloride

SKU: orb1709508

Description

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	2319722-40-0
MW	366.24
Purity	99.38%
Formula	C₁₇H₁₇Cl₂N₃O₂
SMILES	CC1=NN=C(C2=CC=C(N)C=C2)C3=C(C=C4OCOC4=C3)C1.Cl.Cl
Target	iGluR,GluR
Solubility	DMSO:1 mg/mL (2.73 mM)

Bioactivity

−

Target IC50	AMPA receptor:11 μM \|Kainate receptor:7.5 μM
In Vivo	GYKI 52466 dihydrochloride (1.76-13.2 mg/kg; single administration), given by intraperitoneal injection to DBA/2 mice, was able to provide effective anticonvulsant protection against sound-induced seizures. Read more...
In Vitro	In cultured rat hippocampal neurons, GYKI 52466 dihydrochloride (0.3-100 μM) was able to inhibit inward currents activated by AMPA and Kainate receptors. Read more...

Storage & Handling

−

Storage	keep away from direct sunlight,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Kainate receptor, GYKI52466, GYKI 52466 2HCl, GYKI 52466 dihydrochloride, GYKI-52466, GYKI52466 dihydrochloride, GYKI-52466 dihydrochloride, GYKI 52466, AMPA receptor, AMPA

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

91820611 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols