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H3R antagonist 6

SKU: orb3136847

Description

H3R antagonist 6 (Compounds 3) (H3-2406) is a histamine receptor 3 (H3R) antagonist with an IC50 of 5.6 nM. The 18F-labeled version exhibits high radiochemical yield, molar activity, and moderate brain uptake, although it shows off-target binding with the Sigma-1 receptor. It serves as a radioligand for positron emission tomography (PET) imaging in the study of central nervous system (CNS) diseases.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2183338-59-0
MW316.41
FormulaC19H25FN2O
SMILESO=C(N1CCN(CC1)C2CCCC2)C3CC3C4=CC=C(F)C=C4
TargetSigma receptor,Histamine Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information