Halobetasol propionate

SKU: orb1300689

Description

Halobetasol propionate is a synthetic corticosteroid used in research for its potent anti-inflammatory and antipruritic effects. It acts by binding to glucocorticoid receptors, inhibiting arachidonic acid release and subsequent prostaglandin synthesis. This mechanism is studied in vitro and in vivo models of dermatological conditions like psoriasis and eczema to understand cutaneous inflammation and vascular responses.

Research Area

Metabolism Research

Images & Validation

−

Key Properties

−

CAS Number	66852-54-8
MW	484.96
Purity	99.89% (May vary between batches)
Formula	C₂₅H₃₁ClF₂O₅
SMILES	CCC(=O)O[C@@]1([C@@H](C)CC2C3C[C@H](F)C4=CC(=O)C=CC4(C)[C@@]3(F)C(O)CC12C)C(=O)CCl
Target	Others,Glucocorticoid Receptor,Phospholipase
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.8 mM);DMSO:90 mg/mL (185.58 mM);Ethanol:36 mg/mL (74.23 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

−

In Vitro

Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. The initial interaction, however, is due to the drug binding to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

CGP 14458, CGP14458, CGP-14458, BMY 30056, BMY30056, BMY-30056, Halobetasol (propionate), Halobetasol Propionate, inhibit, Inhibitor, PLA2, Ulobetasol Propionate, Ulobetasol propionate

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

48175 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols