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Halofenozide

SKU: orb1221160

Description

Halofenozide is an ecdysteroid agonist and used as a pesticide.

Images & Validation

Key Properties

CAS Number112226-61-6
MW330.81
Purity>98% (HPLC)
FormulaC18H19ClN2O2
SMILESCC(C)(C)N(NC(=O)c1ccc(Cl)cc1)C(=O)c1ccccc1
Targetothers
SolubilityDMSO:10 mM

Bioactivity

In Vivo
After topical application of Halofenozide (RH-0345; 5 and 10 μg) on adult females, the highest dose (10 μg) reduces significantly the reproductive parameters scored: namely the oviposition period, the fecundity and the egg viability. Halofenozide at the two doses tested (5 and 10 μg) causes smaller eggs with a decrease in length, width and volume. Animal model: Newly emerged (0-day-old) adult females of T. molitor. Dosage: 5 and 10 μg. Administration: Topically applied. Result: Caused smaller eggs with a decrease in length, width and volume at the two doses tested (5 and 10 μg).
In Vitro
Halofenozide (RH-0345) reduces both growth and development of oocytes in vitro. Cell Viability Assay Cell line: Cultured ovarieswere dissected from female adult beetles of mealworm, Tenebrio molitor (T. molitor) Concentration: 1 μM and 10 μM. Incubation time: 4 days. Result: Did not cause a significant effect on ecdysteroid amounts in the culture medium using ovaries from 0- and 2-day-old females at 10 μM. Caused a small significant increase of the amounts of ovarian ecdysteroids in the culture medium at 1 μM in the culture medium and with 2-day-old ovaries.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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    330.81

    C18H19ClN2O2

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 1 ml x 10 mM (in DMSO), 100 mg
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