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Halofuginone HBr

SKU: orb1304120

Description

Halofuginone hydrobromide is a semisynthetic alkaloid that suppresses collagen type I and MMP-2 gene expression. This inhibition of key fibrotic and angiogenic promoters makes it a valuable research tool for studying fibroproliferative diseases, tumor stroma, and cancer progression in both cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

CAS Number64924-67-0
MW495.6
Purity> 95%
FormulaC16H17BrClN3O3 • HBr
SMILESBr.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
TargetCalcium Channel,Parasite,Sodium Channel,TGF-beta/Smad,DNA/RNA Synthesis
SolubilitySoluble in DMSO (up to 50 mg/ml)

Bioactivity

Target IC50
Prolyl-tRNA synthetase:18.3±0.5 nM(ki)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NSC 713205
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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10 mg
$ 190.00
50 mg
$ 270.00
DispatchUsually dispatched within 3-5 working days
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