Halofuginone HBr

SKU: orb1304120

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Description

Halofuginone hydrobromide is a semisynthetic alkaloid that suppresses collagen type I and MMP-2 gene expression. This inhibition of key fibrotic and angiogenic promoters makes it a valuable research tool for studying fibroproliferative diseases, tumor stroma, and cancer progression in both cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	64924-67-0
MW	495.6
Purity	> 95%
Formula	C₁₆H₁₇BrClN₃O₃ • HBr
SMILES	Br.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
Target	DNA/RNA Synthesis,Sodium Channel,Calcium Channel,Parasite,TGF-beta/Smad
Solubility	Soluble in DMSO (up to 50 mg/ml)

Bioactivity

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Target IC50	Prolyl-tRNA synthetase:18.3±0.5 nM(ki)

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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NSC 713205

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Compound Identifiers

PubChem CID

11591339 ↗

Key Properties

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No computed properties available.

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