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HBI-2375

SKU: orb3136860

Description

HBI-2375 (HYBI-084) is a selective inhibitor that penetrates the blood-brain barrier and is orally active, targeting the MLL1-WDR5 interaction. It inhibits WDR5 with an IC50 of 4.48 nM and demonstrates antiproliferative activity in MV4;11 leukemia cells with an IC50 of 3.17 µM. Furthermore, HBI-2375 disrupts histone methyltransferase activity in cancer cells and is useful for researching leukemia, glioma, and glioblastoma.

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Key Properties

CAS Number2982574-79-6
MW616.11
FormulaC29H36ClF2N9O2
SMILESN(C(=O)C1=C(Cl)C(C)=C(F)C(N)=C1)C2=C(C=C(F)C(=C2)N3C=C(C(=O)N4CCN(C)CC4)N=N3)N5C[C@@H](C)N(C)[C@@H](C)C5
TargetHistone Methyltransferase,JAK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quality Guarantee

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HBI-2375 (orb3136860)

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