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Helichrysetin

SKU: orb1297344

Description

Helichrysetin

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number62014-87-3
MW286.28
Purity96.32% (May vary between batches)
FormulaC16H14O5
SMILESCOc1cc(O)cc(O)c1C(=O)\C=C\c1ccc(O)cc1
TargetApoptosis|||HIV Protease
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (6.99 mM);DMSO:22.5 mg/mL (78.59 mM)

Bioactivity

In Vitro
Searching for anti-HIV-1 protease (PR) inhibitors of Thai medicinal plants led to the isolation of a new cyclohexenyl chalcone named panduratin C (1) and chalcone derivatives (2-6) from the methanol extract of Boesenbergia pandurata rhizomes. The known compounds were identified to be panduratin A (2), hydroxypanduratin A (3), Helichrysetin (4), 2',4',6'-trihydroxyhydrochalcone (5), and uvangoletin (6). The structures of all compounds were elucidated on the basis of chemical and spectroscopic methods. It was found that 3 possessed the most potent anti-HIV-1 PR activity with an IC50 value of 5.6 microM, followed by 2 (IC50 = 18.7 microM), whereas other compounds exhibited only mild activity.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cycle, cell, Apoptosis, anticancer, Inhibitor, inhibit, Helichrysetin, ID2, HIV Protease, HIVProtease, HIV, growth, DCIS

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  • Helichrysetin [orb1940921]

    >98% (HPLC)

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    286.3

    C16H14O5

    5 mg, 500 mg, 1 g, 100 mg, 200 mg, 10 mg, 25 mg
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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 270.00
5 mg
$ 290.00
10 mg
$ 410.00
25 mg
$ 640.00