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HO-3867

SKU: orb1300681

Description

HO-3867 is a curcumin analog that functions as a selective STAT3 inhibitor. It is utilized in cancer research to study STAT3-driven pathways, demonstrating activity in both in vitro cell-based assays and in vivo tumor models.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1172133-28-6
MW464.55
Purity99.21% (May vary between batches)
FormulaC28H30F2N2O2
SMILESCC1(C)C=C(CN2C\C(=C/c3ccc(F)cc3)C(=O)\C(C2)=C\c2ccc(F)cc2)C(C)(C)N1O
TargetApoptosis,STAT
SolubilityH2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:6 mg/mL (12.92 mM);DMSO:11 mg/mL (23.68 mM);10% DMSO+90% Corn Oil:1 mg/mL (2.15 mM)

Bioactivity

Cell Research
Cell viability is determined by a colorimetric assay using MTT. In the mitochondria of living cells, yellow MTT undergoes a reductive conversion to formazan, producing a purple color. Cells, grown to ~80% confluence in 75-mm flasks, are trypsinized, counted, seeded in 96-well plates with an average population of 7,000 cells/well, incubated overnight, and then treated with HO-3867 for 24 h. All experiments are done using 8 replicates and repeated at least three times. (Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, inhibit, Inhibitor, HO 3867, HO3867, HO-3867, STAT3, STAT
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

HO-3867 (orb1300681)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,690.00
5 mg
¥ 1,690.00
10 mg
¥ 2,210.00
25 mg
¥ 4,030.00
50 mg
¥ 5,980.00
100 mg
¥ 9,230.00
DispatchUsually dispatched within 3-5 working days
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