HP1a (M) Antibody, Rabbit Polyclonal

SKU: orb66782

Description

Rabbit polyclonal to HP1a.Heterochromatin protein 1-alpha (HP1a) is a highly conserved nonhistone protein belonging to theheterochromatin protein family. The N-terminal chromodomain of HP1a binds to histone H3 tailsmethylated at Lys-9 (H3K9me), leading to epigenetic repression. Conversely, it is excluded fromchromatin when Tyr-41 of histone H3 is phosphorylated (H3Y41ph). It may interact with lamin-Breceptor. HP1a is involved in the formation of functional kinetochore through interaction with MIS12complex proteins.

Research Area

Epigenetics

Images & Validation

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Tested Applications	WB
Dilution range	WB:1:1000-1:5000
Reactivity	Human, Mouse

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	middle region of mouse HP1a
Molecular Weight	22
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-HP1a antibody,anti-Cbx5 antibody,anti-HP1 antibody,anti-2610029O15Rik antibody,anti-C75991 antibody

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Western blot analysis of total cell extracts from mouse thymus using HP1a antibody

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UniProt

Q61686

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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