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HPG1860

SKU: orb2695202

Description

HPG1860 is a potent FXR agonist with an EC50 of 18 nM in cellular reporter assays. In a mouse NASH model, it significantly lowers serum ALT and cholesterol, while reducing hepatic steatosis, inflammation, and fibrosis, demonstrating therapeutic potential for metabolic liver disease research.

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Key Properties

CAS Number2226133-29-3
MW573.49
FormulaC27H26Cl2N4O4S
SMILESC(C=1C(=NOC1C2CC2)C3=C(Cl)C=CC=C3Cl)N4C[C@@H](C)N(CC4)C5=NC=6C(S5)=CC(C(O)=O)=CC6OC

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

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HPG1860 (orb2695202)

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