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Human Cadherin-17 / CDH17 (567-667) Protein, Fc Tag

SKU: orb3158109

Description

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Images & Validation

Application Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 37.3 kDa. The protein migrates as 43-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

Expression SystemHEK293
TargetCadherin-17
ReactivityHuman
TagC-Fc
Expression RegionSer 567 - Leu 667
Endotoxins1.0 EU per μg
ConjugationUnconjugated
MW37.3 kDa
Purity85%

Storage & Handling

Storage-20°C
Form/AppearancePowder
Buffer/Preservatives20 mM Tris, 150 mM NaCl, pH 8.0
Expiration Date6 months from date of receipt.
DisclaimerFor research use only
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NCBI Reference Sequences

Associated Accession Numbers
Curated reference sequences for the gene transcript and protein product
RefSeqQ12864

Protocol Information

Protein Handling and Storage Guide
Protein Handling Guide
View Guide