Human IL-31 RA & OSMR Protein, Fc Tag (MALS verified)

SKU: orb3158169

Description

Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMR beta but also in a homomeric receptor complex.

Images & Validation

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Application Notes	Human IL-31 RA & OSMR Protein, Fc Tag, produced by co-expression of IL-31 RA and OSMR, has a calculated MW of 165.7 kDa. This protein carries a human IgG1 Fc tag at the C-terminus. The protein migrates as 200-250 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

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Expression System	HEK293
Target	IL-31 RA & OSMR
Reactivity	Human
Tag	C-Fc
Molecular Weight	165.7 kDa
Expression Region	Ala 20 - Glu 519 (IL-31 RA) & Glu 28 - Met 740 (OSMR)
Purity	90%
Endotoxins	1.0 EU per μg
Conjugation	Unconjugated

Storage & Handling

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Storage	-20°C
Form/Appearance	Powder
Buffer/Preservatives	PBS, pH 7.4
Expiration Date	6 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

IL-31 RA & OSMR

RefSeq:Q8NI17, Q99650

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

RefSeq	Q8NI17, Q99650

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