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Human PCSK9 Protein, Fc Tag

SKU: orb545756

Description

Human PCSK9, Fc Tag is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gln 692 (Accession # Q8NBP7-1).

Research Area

Metabolism Research

Images & Validation

Application Notes
This protein carries a human IgG1 Fc tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‑covalent interactions and with a calculated MW of 13.8 kDa and 83.7 kDa respectively. The protein migrates as 16 kDa and 100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

Expression SystemHEK293
TargetPCSK9
ReactivityHuman
TagC-Fc
Expression RegionGln 31 - Gln 692
Endotoxins1.0 EU per μg
ConjugationUnconjugated
MW13.8 kDa and 83.7 kDa
Purity90%

Storage & Handling

Storage-20°C
Form/AppearancePowder
Buffer/PreservativesPBS, pH 7.4
Expiration Date6 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • Human PCSK9 Protein, hFc Tag [orb1173897]

    Unconjugated

    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

    The protein has a predicted molecular mass of 97.2 kDa after removal of the signal peptide.The apparent molecular mass of PCSK9-hFc is approximately 100-130 kDa due to glycosylation.

    Mammalian

    50 μg, 10 μg, 100 μg
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UniProt Details

No UniProt data available

NCBI Reference Sequences

Associated Accession Numbers
Curated reference sequences for the gene transcript and protein product
RefSeqQ8NBP7

Protocol Information

Protein Handling and Storage Guide
Protein Handling Guide
View Guide